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Konstantin Muravyov
Konstantin Muravyov

Pobierz Morph Tutaj

Plug in your MPE-capable controller and immediately add bends, slides and pressure for each individual note in a chord. Add subtle expression variations, morph between chords and create evolving sonic textures.

Pobierz Morph tutaj

There are 5 instant-access patches available at any time (inRAM memory). In vector morphing mode dual external controllersallow the active patch to morph in 2-dimensions between the first 4presets. On exit from this mode the resulting patch settings arestored to the 5th preset automatically.

In the setup menu are a series of pages to setup various Motas-6 settings which are stored innon-volatile memory. Settings and options include patch portamento(rate/speed), pitchwheel sensitivity, internal/external clock andtempo, MIDI channel, assignment of M1-M4 modulation sources,morphing modulators, CV/gate settings, global tuning, options forsend/receive MIDI data, display contrast, automatic calibration ofanalogue circuitry and more.

The evolution of costly traits such as deer antlers and peacock trains, which drove the formation of Darwinian sexual selection theory, has been suggested to both reflect and affect patterns of genetic variance across the genome, but direct tests are missing. Here, we used an evolve and resequence approach to reveal patterns of genome-wide diversity associated with the expression of a sexually selected weapon that is dimorphic among males of the bulb mite, Rhizoglyphus robini. Populations selected for the weapon showed reduced genome-wide diversity compared to populations selected against the weapon, particularly in terms of the number of segregating non-synonymous positions, indicating enhanced purifying selection. This increased purifying selection reduced inbreeding depression, but outbred female fitness did not improve, possibly because any benefits were offset by increased sexual antagonism. Most single nucleotide polymorphisms (SNPs) that consistently diverged in response to selection were initially rare and overrepresented in exons, and enriched in regions under balancing or relaxed selection, suggesting they are probably moderately deleterious variants. These diverged SNPs were scattered across the genome, further demonstrating that selection for or against the weapon and the associated changes to the mating system can both capture and influence genome-wide variation.

Shown are the generations when sampling for resequencing was performed (blue boxes), from which Illumina reads were mapped to the reference genome and genomic analysis performed. Also shown are the generations at which morph proportion assays were performed (red boxes) to track morph proportion in experimental evolution populations and when phenotypic assays were performed (purple boxes), including a brief description.

That we do not observe an overall increase in female fecundity in F-lines may be reconciled if the benefits of purging deleterious mutations are counteracted by an increase in the strength of intra-locus sexual conflict (IASC) occurring between females and males with greatest expression of SST39,40,41. This increased strength of IASC has previously been described in R. robini inbred lines founded by fighters or scramblers67 and within populations selected for each male morph39, in which females derived from fighter treatments had decreased fitness compared to those from scrambler treatments. This indicates higher fitness of daughters of the less sexually competitive scramblers69, which has been proposed to contribute to their maintenance in populations39. In the case of our populations, these negative effects of IASC in F-lines were probably compensated by the positive effects of purging deleterious mutations. Such purging was minimized in the inbred lines in Łukasiewicz et al.67 and greatly limited in the populations in Plesnar-Bielak et al.39, which were an order of magnitude smaller than ours, thus limiting the effectiveness of selection. This potentially explains the differences in results and is suggestive that the impact of IASC on population fitness may interact with Ne.

As IASC is probably reduced in S-lines39,67,72, we assumed that polymorphisms previously maintained under balancing selection by IASC within the stock population, with mixed male morphs, were more likely to be lost from S-lines compared to F-lines. We consequently predicted that the windows containing diverged SNPs fixed or nearly fixed (frequency of minor alleles

One generation before establishing experimental evolution populations the proportion of male morphs was determined from 176 random males, indicating a roughly equal morph ratio (95 fighters, 81 scramblers) of the stock population (Extended Data Fig. 3).

Analysis of male morph proportion was performed using a generalized linear mixed model with binomial error structure, fitted using lme4 (ref. 96). Where the proportion of desired morph was compared in model with morph selection and generation (as a factor) including their two-way interaction as explanatory variables, and population included as a random effect.

All fecundity data were analysed using generalized linear mixed models with Poisson error structures, fitted using lme4. Due to the differences in stock population males used between F45 and earlier generations, and slightly different rearing conditions between females in the fecundity assays from generations F20 and F32, they were analysed separately from data collected in F45. However, we noted that the fecundity of females in Fig. 5a was comparable to the outbred females in Fig. 5b. Explanatory variables fitted to fecundity data from F20 and F32 were, morph selection treatment, generation, including their two-way interaction term, and stock male morph. The explanatory variables fitted to fecundity data from inbreeding depression data were, morph selection treatment and status of female (that is, inbred or outbred), including their two-way interaction term. In both analyses, we included population as a random effect and an observation level random effect to account for overdispersion, we omitted fitting random slopes due to issues with increasing the complexity of random effects close to reaching a singular fit. Females that died before the end of the fecundity assay and those that laid zero eggs were removed from analysis. This excluded five females from F20 (three F-line and two S-line), 20 from F32 (13 F-line and seven S-line) and 16 from F45 (three inbred and three outbred F-line, and nine inbred and one outbred S-line).

Of the many arresting moments that fill LCD Soundsystem's This Is Happening, perhaps the most unexpected comes less than halfway through album opener "Dance Yrself Clean." The seemingly unassuming, low-key rumble of a song morphs from its mumbled beginnings into an outsized flash of synth ballast and wailing vocals. The sudden shift is like the flicking on of a light, the perfect example of frontman-songwriter-mastermind James Murphy's effortless balance of restraint and release, organic rock and electro pop, and muted cool and vibrant emotion. This study in contrasts pervades LCD Soundsystem's third, and possibly final, release--an album where Murphy refracts images of heartbreak and longing through the scattered light of a disco ball.

This face brings together colors that represent the LGBT community. The threads morph to create the time and respond to the movement of your wrist. You can also tap each thread or rotate the Digital Crown to send a vibration across them. 041b061a72


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